St. John's Wort (Hypericum perforatum) is an herbal tranquilizer and antidepressant. The active components include hypericin and hyperforin. This herb raises levels of serotonin, norepinephrine and dopamine which helps maintain normal mood and emotional stability.
In dogs and cats this herb is used for depression, separation and certain forms of aggression. Some supplements combine this herb with other sedating herbs like Valerian, passion flower and others. I have given this to my cat with seizures to help calm her. St John's Wort may also be helpful as an antibacterial and antiviral agent.
Dose 1/8 to 1/4 of the human dose recommended on the label.